Experiment and model for surface tensions of 2?diethylaminoethanol?N?(2?aminoethyl)ethanolamine, 2?diethylaminoethanol?N?methyl?1,3?propane?diamine and 2?diethylaminoethanol?1,4?butanediamine aqueous solutions

2019/6/16

Total chemical synthesis of the linear tetrasaccharide repeating unit β-D-Glc-(1?→?2)-α-L-Rha-(1?→?3)-α-L-Rha-(1?→?2)-α-L-Rha-CH2CH2NH2 of the O-antigen from Azospirillum brasilense Jm125A2 is accomplished through rational protecting group manipulations of commercially available monosaccharides and stereoselective glycosylations. The target tetrasaccharide in the form of its 2-aminoethyl glycoside is obtained in ～24% yield over 10 steps following a linear strategy. The structure is particularly suitable for further glycoconjugate formation through the terminal free amine without hampering the reducing end stereochemistry.